Weight Loss and Leptin Supplements

Since the discovery of leptin in 1994, many have hoped that the hormone would be a promising weight-loss treatment for humans. Leptin acts as a signal to help the body decide when it has eaten enough food to feel full. The amount of leptin in the blood has been directly linked to body fat.

After receiving leptin replacement therapy, research subjects with a recessive mutation in the obesity (ob) gene - a population both deficient in Leptin and morbidly obese - lost about half of their body weight while regulating their own food intake. (Medical news Today 4/5/2005).

If you take it at face value, it seems as if the research is saying that more leptin will help you lose weight. This research refers to subjects with a genetic basis for obesity who were deficient in leptin. But obese individuals tend to have more and larger leptin-producing fat cells than thinner people. They simply are not getting vital chemical signals to their brains that tell them to stop eating.

To illustrate my point: Read more

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Leptin Resistance and Weight Loss

Recent research into leptin has revealed what is likely to be very important in the control of appetite, weight loss and the regulation of body weight. Advances in leptin research and its role in the control of obesity would lead to reductions in diabetes, coronary heart disease and many forms of cancer, all of which are increased in obesity.

American adults are overweight and more than 30 percent are obese. Currently 50 million Americans suffer from metabolic syndrome - a disease associated with obesity and encompassing coronary artery disease and type 2 diabetes.

Leptin leapt into the headlines when it was identified in 1995 as a protein that triggers weight loss in mice.

Leptin (the Greek term for thin) is a hormone released by your fat cells. When you lose fat, leptin levels drop and when you gain fat, leptin levels rise.

Leptin affects our weight and our appetites. Levels of leptin rise just before a meal and fall when people are full. It is now known that leptin not only can affect the chemical responses that affect how hungry you are but also can affect the wiring of your brain. Read more

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